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ArticleBiopharma innovation surges as regulation and risk rise
Writer: Mirella Franzese Key points: • Regulatory complexity and policy uncertainty are slowing drug approvals and dampening investor confidence. • Rising specialty drug complexity is fragmenting supply chains and driving...
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ArticleInvest: Philadelphia leadership conference to highlight eds and meds hub
Key points: • The Invest: Philadelphia Leadership Summit will spotlight collaboration across the region’s eds and meds ecosystem. • Panels will explore workforce readiness, healthcare partnerships, research innovation, and infrastructure...
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Writer: Juan Tagle, Director, Palm Beach Capital Key points: • Interest rates, private credit competition, and M&A activity are the hey elements for midmarket companies and private investors to consider....
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Latest Articles
5 Min ReadBiopharma innovation surges as regulation and risk rise
Writer: Mirella Franzese Key points: • Regulatory complexity and policy uncertainty are slowing drug approvals and dampening investor confidence. • Rising specialty drug complexity is fragmenting supply chains and driving higher costs and access challenges. • Pricing pressure on branded pharmaceuticals is intensifying amid affordability concerns and federal intervention. January 2026 — The U.S. biopharmaceutical industry has never been more innovative — or more vulnerable to fragmentation. Even as scientific...
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2026: Going All In on AI
As the year comes to a close, I always find myself reflecting. Not just on what happened over the last 12 months, but on
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With the Invest: Business Sentiment Survey, we take a deep dive into our markets through an on-the-ground approach to tell you why you should be doing business there.
The Regional Economic Sentiment Index, drawn from the Invest: Business Sentiment Survey (I:BSS), tracks perceptions of economic strength across 20 U.S. metro areas. The index is based on a standardized question posed to senior executives and public officials featured in Invest: reports, asking them to rate the strength of their regional economy on a scale of 1 to 5 (5 being strongest).
Sentiment remained stable from late 2023 through most of 2025, but it became more volatile following the January 2025 political transition, as a new wave of tariff activity and shifting trade expectations introduced greater uncertainty. After a mid-2025 slump and a brief rebound in early fall, sentiment declined sharply at year-end, with December 2025 marking the weakest reading of the series.
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caa annual business guides take a 360° view of each metro area we cover through in-depth analysis, interviews with local business and political leaders and comprehensive data and statistics. Click on a cover to read more.
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caa is an integrated media company that connects the dots in the markets it covers, providing business intelligence to businesses, executives, investors, and entrepreneurs across its digital and print platforms. It produces annual economic reports and engaging content on important US metro regions, while forging strategic connections through its conferences and events.
